Hopkins was born in Margam, Port Talbot, Wales. The son of Muriel Anne and Richard Arthur Hopkins.

A loner with dyslexia, he found that he would rather immerse himself in art, such as painting and drawing or playing the piano, than attend to his studies. In 1949, to instill some discipline, his parents insisted he attend Jones' West Monmouth Boys' School in Pontypool, Wales. He remained there for five terms and was then educated at Cowbridge Grammar School, Cowbridge, Wales.

Hopkins was influenced and encouraged to become an actor by compatriot Richard Burton, whom he met briefly at the age of 15. To that end, he enrolled at the Welsh College of Music and Drama in Cardiff, Wales from which he graduated in 1957. After a two-year spell in the Army for National Service, he moved to London where he trained at RADA.

In 1965, after several years in repertory, he was spotted by Sir Laurence Olivier, who invited him to join the Royal National Theatre. Despite his success at the National, Hopkins tired of repeating the same roles nightly and yearned to be in movies. In 1968, he got his break in The Lion in Winter playing Richard I, along with future James Bond star Timothy Dalton, who played Philip II of France. He made his small-screen debut in a 1967 BBC broadcast of A Flea in Her Ear. He has since gone on to enjoy a long career, winning many plaudits and awards for his performances.

Hopkins' most famous role is the cannibalistic serial killer Hannibal Lecter in The Silence of the Lambs (for which he won the Academy Award for Best Actor in 1992) opposite Jodie Foster as Clarice Starling, who also won for Best Actress. In addition, the film won Best Picture, Best Director and Best Adapted Screenplay. It is the shortest lead performance to win an Oscar, as Hopkins only appears for about seventeen minutes.

As of 2007, Hopkins resides in the United States. He had moved to the country once before during the 1970s to pursue his film career, but returned to Britain in the late 1980s. He became a naturalized citizen on April 12, 2000, and celebrated with a 3,000-mile road trip across the country.

Hopkins has been married three times. His first two wives were Petronella Barker (1967–1972) and Jennifer Lynton (1973–2003). He is now married to Colombia-born Stella Arroyave. He has a daughter from his first marriage, Abigail Hopkins (born 1967), an actress and singer.

He has offered his support to various charities and appeals, notably becoming President of the National Trust's Snowdonia Appeal, raising funds for the preservation of the Snowdonia National Park and to aid the Trust's efforts to purchase parts of Snowdon. A book celebrating these efforts, Anthony Hopkins' Snowdonia, was published together with Graham Nobles. He was a Guest of Honour at a Gala Fundraiser for Women in Recovery, Inc., a Venice, California-based non-profit organization offering rehabilitation assistance to women in recovery from substance abuse. He is also a volunteer teacher at the Ruskin School of Acting in Santa Monica, California, where he resides.

Hopkins is an acknowledged alcoholic who has been sober since 1975.

Hopkins is a prominent member of environmental protection group Greenpeace and as of early 2008 featured in a television advertisement campaign, voicing concerns about Japan's continuing annual whale slaughter.

He is an admirer of the comedian Tommy Cooper. On 23 February 2008, as patron of The Tommy Cooper Society, the actor unveiled a commemorative statue in the entertainer's home town of Caerphilly. For the ceremony, Hopkins donned Cooper's trademark fez and performed a comic routine.

Hopkins is a talented pianist. In 1986, he released a single called "Distant Star". It peaked at #75 in the UK charts. In 2007, he announced he would retire temporarily from the screen to tour around the world.

In 1996, Hopkins directed his first film, August, an adaptation of Chekhov's Uncle Vanya. His first screenplay, an experimental drama called Slipstream, which he also directed and scored, premiered at the Sundance Film Festival in 2007.

Hopkins is a fan of the BBC sitcom Only Fools and Horses, and once remarked in an interview how he'd love to appear in the series. Writer John Sullivan saw the interview, and with Hopkins in mind created the character Danny Driscoll, a local villain. However, filming of the new series coincided with the filming of The Silence of the Lambs, making Hopkins unavailable. The role instead went to his friend Roy Marsden.

Anthony Hopkins's Photos

Besides his win for The Silence of the Lambs, Hopkins has been Oscar-nominated for The Remains of the Day (1993), Nixon (1995) and Amistad (1997).

Hopkins won the BAFTA Award for Best Actor in 1973 for his performance as Pierre Bezukhov in the BBC's production of War and Peace, and additionally for The Silence of the Lambs and Shadowlands. He received nominations in the same category for Magic and The Remains of the Day and as Best Supporting Actor for The Lion in Winter.

He won Emmy Awards for his roles in The Lindbergh Kidnapping Case and The Bunker, and was Emmy-nominated for The Hunchback of Notre Dame and Great Expectations. He won the directing and the acting award, both for Slipstream, at Switzerland's Locarno International Film Festival.